Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A pathologic basis for Kleine-Levin syndrome

S Carpenter, R Yassa, R Ochs

    Archives of Neurology
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    HnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing of <i>Irgm1</i>.

    Infection and immunity·2026
    Same author

    HnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing of <i>Irgm1</i>.

    bioRxiv : the preprint server for biology·2025
    Same author

    High-power Raman lasing and efficient anti-Stokes generation in mm-sized crystalline disk resonators.

    Optics letters·2024
    Same author

    A national survey investigating the impact of the COVID-19 pandemic on core and higher breast radiology training in the UK.

    Clinical radiology·2022
    Same author

    Operationalising coastal resilience to flood and erosion hazard: A demonstration for England.

    The Science of the total environment·2021
    Same author

    Complications following Suture Button Use for Femoral Graft Fixation in Arthroscopic Anterior Cruciate Ligament Reconstruction: A Systematic Review.

    The journal of knee surgery·2020

    Kleine-Levin syndrome, typically starting in adolescence, presented atypically in a 39-year-old. Autopsy revealed thalamic lesions, suggesting a potential viral etiology for this rare neurological disorder.

    Area of Science:

    • Neurology
    • Neuroscience
    • Pathology

    Background:

    • Kleine-Levin syndrome (KLS) is a rare neurological disorder characterized by recurrent episodes of hypersomnolence and cognitive/behavioral disturbances.
    • Typical onset for KLS is during adolescence, making late-onset cases particularly unusual.

    Observation:

    • A patient with KLS, who experienced onset at 39 years of age, died during a symptomatic period.
    • Autopsy examination was performed to investigate the neuropathological basis of the late-onset KLS.

    Findings:

    • Autopsy revealed both recent and old lesions predominantly in the medial thalamus, affecting intralaminar, medial, and dorsal nuclei, as well as the pulvinar.
    • Significant microglial infiltration was observed, yet minimal neuronal loss was present.
    • The hypothalamus remained unaffected by the pathological process.

    Related Experiment Videos

    Implications:

    • The specific thalamic involvement and inflammatory response in this late-onset KLS case suggest a potential viral etiology.
    • These findings contribute to understanding the neuropathology of Kleine-Levin syndrome and may guide future research into its causes and potential treatments.