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Bone lesions in chronic myelogenous leukaemia
Acta Medica Scandinavica
|January 1, 1981
Summary
Bone lesions are common in chronic myelogenous leukaemia (CML), often preceding pain. Imaging reveals abnormalities, with distinct patterns in acute vs. chronic phases, guiding potential treatment strategies.
Area of Science:
- Hematology
- Nuclear Medicine
- Radiology
Background:
- Chronic myelogenous leukaemia (CML) is a myeloproliferative neoplasm.
- Bone involvement is a recognized complication of CML.
Observation:
- Bone scintigraphy revealed abnormalities in 67% of CML patients.
- Radiography showed abnormalities in 29% of CML patients.
- Bone pain was reported by nearly all patients before osseous lesions were evident.
Findings:
- Juxta-articular uptake on radiographs was more common in acute phase CML.
- Focal uptake areas on scintigraphy were frequent in chronic phase CML.
- Hypercalcaemia and bone lysis were observed in a patient with blastic transformation.
Implications:
- Bone imaging is crucial for assessing CML-related skeletal complications.
- Distinct imaging patterns may differentiate CML phases.
- Aggressive treatment, including chemotherapy and irradiation, may be beneficial for extensive bone destruction even in remission.