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A prospective study of persistent diarrhoea

T D Bolin, A E Davis, V M Duncombe

    Australian and New Zealand Journal of Medicine
    |February 1, 1982
    PubMed
    Summary
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    This study investigated 100 diarrhea patients, finding Irritable Bowel Syndrome (IBS) in 28%. Key IBS indicators include pain with urgency, while blood or weight loss suggest other conditions.

    Area of Science:

    • Gastroenterology
    • Clinical Medicine

    Background:

    • Diarrhea is a common symptom with diverse etiologies.
    • Identifying Irritable Bowel Syndrome (IBS) requires distinguishing it from organic diseases.

    Purpose of the Study:

    • To identify causes of diarrhea in a prospective cohort.
    • To determine the prevalence of IBS and associated symptoms.
    • To identify diagnostic symptom complexes for IBS.

    Main Methods:

    • Prospective study of 100 patients presenting with diarrhea.
    • Clinical evaluation, diagnostic investigations including sigmoidoscopy and small bowel biopsy.
    • Assessment for lactase deficiency, Giardia lamblia, and inflammatory bowel disease.

    Main Results:

    Related Experiment Videos

    • Irritable Bowel Syndrome (IBS) diagnosed in 28% of patients.
    • Lactase deficiency found in 40% of IBS patients.
    • Pain with urgency was common in IBS; urgency without pain suggested organic lesions.
    • Blood in stool and weight loss were key differentiators for IBS.
    • Giardia lamblia identified in 9% of patients.
    • Inflammatory bowel disease present in 14% of patients.
    • Drug-induced diarrhea occurred in 10% of patients.

    Conclusions:

    • Sigmoidoscopy and small bowel biopsy are crucial diagnostic tools for diarrhea.
    • Specific symptom patterns can help differentiate IBS from organic colonic diseases.
    • Lactase deficiency is prevalent in IBS patients with diarrhea.