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Updated: Aug 19, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Aspergillosis of the nose and paranasal sinuses

J L Romett, R K Newman

    The Laryngoscope
    |July 1, 1982
    PubMed

    Insights

    Aspergillosis, a fungal infection, is increasingly seen in the sinonasal tract. Management involves surgical treatment, with antifungals used for severe cases.

    Area of Science:

    • Otorhinolaryngology
    • Mycology
    • Infectious Diseases

    Background:

    • Aspergillosis is an emerging pathogen in the sinonasal tract.
    • Bacterial sinusitis can promote the growth of Aspergillus, a common contaminant.
    • Aspergillus fumigatus is the most frequent species causing paranasal sinus issues in the U.S.

    Observation:

    • Two patient cases, one healthy and one with malignancy, highlight diagnostic and management challenges.
    • The maxillary antrum is the most commonly affected sinus site.
    • Infections are categorized as non-invasive or fulminant.

    Findings:

    • Aspergillosis is increasingly identified in immunocompromised and debilitated individuals.
    • Surgical intervention is the primary treatment modality.
    • Antifungal agents are reserved for central nervous system involvement and fulminant disease.

    Implications:

    • Understanding the varied clinical presentations of sinonasal aspergillosis is crucial for timely diagnosis.
    • Effective management strategies require a combination of surgical and medical approaches.
    • Further research into risk factors and preventative measures for sinonasal aspergillosis is warranted.

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