Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

The pulmonary interstitium in capillary exchange

A E Taylor, J C Parker, P R Kvietys

Annals of the New York Academy of Sciences

|January 1, 1982

Summary

Edema safety factors, including tissue fluid pressure and colloid osmotic pressure, protect the lungs from excessive fluid buildup. These forces oppose changes in pulmonary capillary pressure, preventing alveolar flooding.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Epidemiology of dog bite and strike related hospital admissions in Scotland, 1997 to 2022.

Public health·2025

Same author

Inflammation dynamically regulates steroid hormone metabolism and action within macrophages in rheumatoid arthritis.

Journal of autoimmunity·2024

Same author

Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial.

European journal of endocrinology·2022

Same author

Evaluation of Locoregional Recurrence Patterns Following Adjuvant (Chemo)Radiotherapy for Oral Cavity Carcinoma.

Clinical oncology (Royal College of Radiologists (Great Britain))·2019

Same author

Locus of control is associated with tobacco and alcohol consumption in young adults of the Avon Longitudinal Study of Parents and Children.

Royal Society open science·2019

Same author

Simultaneous parameter estimation and variable selection via the logit-normal continuous analogue of the spike-and-slab prior.

Journal of the Royal Society, Interface·2019

Area of Science:

Pulmonary physiology
Edema formation and prevention

Background:

Pulmonary capillaries normally filter fluid, influencing tissue fluid pressure and colloid osmotic pressure.
These forces collectively act as edema safety factors, protecting lung tissue from excessive fluid accumulation.

Purpose of the Study:

To elucidate the mechanisms and contributions of edema safety factors in preventing pulmonary edema.
To analyze the roles of tissue fluid pressure, colloid osmotic pressure, and lymph flow in opposing increases in pulmonary capillary pressure.

Main Methods:

The study reviews known physiological responses to increased pulmonary capillary pressure.
It discusses the quantitative contributions of interstitial colloid osmotic pressure and tissue pressure.
It explores the potential role of interstitial fluid pressure gradients and lymph flow in edema safety.

Main Results:

Decreased interstitial colloid osmotic pressure accounts for about 50% of the safety factor against increased pulmonary capillary pressure.
Increased tissue pressure with hydration also significantly opposes capillary filtration.
The contribution of lymph flow is complex, with potential roles for interstitial fluid pressure drops.

Conclusions:

Edema safety factors, primarily interstitial colloid osmotic pressure and tissue pressure, are crucial for preventing pulmonary edema.
Further research is needed to precisely quantify the role of lymph flow and local tissue forces in lung fluid balance.

Related Experiment Videos