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[Steroidogenic activity in the amniotic epithelium]
Bulletin De L'Association Des Anatomistes
|December 1, 1981
Summary
The human amnion, particularly its epithelium, demonstrates steroidogenesis and steroid conversion throughout pregnancy. This suggests a significant role for the amnion in pregnancy physiology.
Area of Science:
- Reproductive Biology
- Endocrinology
- Histology
Context:
- Pregnancy involves complex hormonal regulation.
- The human amnion's role in steroid production has been investigated.
- Histo-enzymologic and submicroscopic techniques were employed.
Purpose:
- To evaluate steroid-producing structures within the human amnion during pregnancy.
- To determine the presence and localization of key enzymes involved in steroidogenesis.
- To assess the amniotic epithelium's potential for steroid production and conversion.
Summary:
- Histo-enzymatic tests revealed 3 beta-hydroxysteroid-dehydrogenase in amniotic epithelial cells and scattered mesenchymal cells throughout pregnancy.
- Steroidogenetic activity was confirmed in the amniotic epithelium using FRIEND and BRASSIL's technique in semithin and ultrathin sections.
- Electron microscopy further supported these findings.
Impact:
- The findings indicate that the amniotic epithelium is a site of steroidogenesis and steroid conversion.
- This suggests the human amnion plays a crucial role in the physiology of pregnancy through steroid metabolism.
- Provides insights into the endocrine functions of the amnion during gestation.