[Functional-morphologic changes in the liver in breast cancer]

The functional state of the liver was studied in 239 patients with mammary gland cancer, 34 of them with intravital morphostructure of the organ. A significant impairment of the absorptive and secretory function of hepatocytes was evident. Also, there was noted an impairment of hepatic microcirculation, the decrease of leukoproductive function and enzymatic activity, changes in the content of the urine and blood cholesterol, in microelements of copper and iron. Marked morphological changes from gradual dystrophy and neocrobiotic processes in hepatocytes to cirrhotic processes in the stroma of the organ were observed. Functional and morphological disorders were observed with certain consistency in all observations, but with a various degree of expression.