Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Matching molecules in the catch mechanism

C Cohen

    Proceedings of the National Academy of Sciences of the United States of America
    |May 1, 1982
    PubMed
    Summary

    A novel model explains molluscan muscle "catch" contraction, proposing paramyosin controls myosin assembly. This unique structure allows extended actin-myosin interactions, crucial for sustained muscle tension.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Does the density of lymphatic vascular space invasion affect the prognosis of stage Ib and IIA node negative carcinoma of the cervix?

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2003
    Same author

    SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation.

    The Journal of pharmacology and experimental therapeutics·2003
    Same author

    Refinement of the Episkin protocol for the assessment of acute skin irritation of chemicals: follow-up to the ECVAM prevalidation study.

    Toxicology in vitro : an international journal published in association with BIBRA·2002
    Same author

    SR141716, a central cannabinoid (CB(1)) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats.

    Behavioural pharmacology·2002
    Same author

    Hepatocellular carcinoma and markers of apoptosis (bcl-2, bax, bcl-x): prognostic significance.

    Applied immunohistochemistry & molecular morphology : AIMM·2002
    Same author

    Crystallographic findings on the internally uncoupled and near-rigor states of myosin: further insights into the mechanics of the motor.

    Proceedings of the National Academy of Sciences of the United States of America·2002

    Area of Science:

    • Muscle Physiology
    • Biochemistry
    • Structural Biology

    Background:

    • Molluscan smooth muscles exhibit a unique 'catch' contraction, allowing sustained tension with low energy expenditure.
    • The molecular mechanisms underlying this specialized contraction remain incompletely understood.
    • Existing muscle models do not fully account for the distinct structural features of molluscan catch muscle.

    Purpose of the Study:

    • To propose a new structural model for molluscan smooth muscle.
    • To explain the molecular basis of the specialized 'catch' contraction.
    • To elucidate the role of paramyosin and myosin in this unique muscle function.

    Main Methods:

    • The study advances a theoretical structural model based on existing knowledge of muscle protein organization.
    • It integrates data on the arrangement of myosin and paramyosin within thick filaments.
    • The model considers the functional implications of protein interactions during muscle contraction.

    Main Results:

    • A novel model depicts myosin as a single layer controlled by an underlying paramyosin core in thick filaments.
    • This organization contrasts with the bundled myosin structure found in other muscle types.
    • The model suggests the paramyosin core facilitates extended actin-myosin linkage lifetimes, enabling the catch state.

    Conclusions:

    • The proposed structural model provides a framework for understanding molluscan muscle catch contraction.
    • The unique arrangement of myosin and paramyosin is key to the prolonged interaction and sustained tension.
    • Modulation of paramyosin phosphorylation may regulate the catch state, offering potential therapeutic targets.

    Related Experiment Videos