Acute myelofibrosis terminating in erythroleukemic state

A patient with acute myelofibrosis associated with erythroleukemia is described. The terminal course of the patient was marked by the erythroblast population in the peripheral blood increasing to a level of 21.8 x 10(3)/mm3, 18% of which were PAS-positive. Possible transformation of acute myelofibrosis into the erythroleukemic state is discussed.