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[HLA-A-, B- and C-geno- and haplotype frequency in Vienna. Analysis of phenotype data]
Abstract:
The HLA-A-A, B, C gene and haplotype frequencies have been calculated by using a computer-algorithm from the HLA phenotypes of 3000 unrelated, healthy inhabitants of Vienna. The frequencies are in good agreement with the figures obtained in a family study. The analysis of the linkage disequilibria involving alleles at 2 out of the 3 loci or at all the 3 loci shows that the disequilibrium between alleles of 2 loci (HLA-A, B, HLA-B, C and HLA-A, C) is stronger than the one observed with alleles at the 3 loci (HLA-A, B, C).