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[Liver status in ostensibly healthy carriers of the hepatitis-Bs antigen]
Insights
Hepatitis B surface antigen (HBs) positive donors often have liver issues. Routine tests are insufficient for one-third of carriers, requiring advanced methods for accurate diagnosis.
Area of Science:
- Hepatology
- Virology
- Clinical Diagnostics
Context:
- Hepatitis B virus (HBV) infection is a global health concern.
- Blood donors are screened for HBs positivity to prevent transmission.
- Assessing liver health in HBs carriers is crucial for early intervention.
Purpose:
- To evaluate liver disturbances in HBs positive blood donor candidates.
- To determine the efficacy of routine clinical-laboratory examinations in identifying liver issues.
- To identify the need for advanced diagnostic methods in HBs carriers.
Summary:
- 185 HBs positive individuals were assessed for liver disturbances.
- Approximately 25% exhibited symptoms or paraclinical deviations.
- 8.11% were diagnosed with chronic hepatitis, 28.65% were suspected of hepatitis, and 63.24% were healthy carriers.
- Routine tests (urine urobillinogen, thymol, transaminase) are adequate for preliminary screening.
- A significant portion (about one-third) of HBs carriers require further immunoserological and immunohistological testing for accurate definition.
Impact:
- Highlights the limitations of standard screening for HBs carriers.
- Emphasizes the need for comprehensive diagnostic approaches in asymptomatic carriers.
- Informs strategies for managing HBs positive blood donors and preventing liver disease progression.
Abstract:
One hundred eighty five ostensibly healthy candidates for blood donors, HBs positive, were examined at the clinic and laboratory as regards liver disturbances. About one fourth of the examined gave either subjective complaints or showed objective changes, deviations in the paraclinic resp. As patients with chronic hepatitis were proved to be 8,11 per cent of the subjects, 28,65 per cent--hepatitis suspected patients and 63,24 per cent were admitted to be healthy antigen-carriers. Urine urobillinogen reaction, thymol test and transaminase are sufficient for the purpose of preliminary screening. About one third of the antigen positive subjects cannot be accurately defined by the routine clinical-laboratory examination and additional immunoserological and immunohistological methods proved to be necessary.