[Relationship between the endocochlear potential and metabolism in the vascular stria of the inner ear]

Effects of dihydrostreptomycin, etacrine acid and ATPh on the endocochlear potential in guinea-pigs depended on the dosage and means of administration. Dihydrostreptomycin suppressed the potential only when perfusing the perilymphatic space or being microinjected into the endolymphatic duct. I. v. administration of etacrine acid suppressed the potential with its following partial restoration. I.v. administration of ATPh in large doses suppressed the potential for a short period but did not prevent the ototoxic effect of etacrine acid. ATPh in small doses did not suppress the potential but exerted the protective effect.