YAC-Lymphoma bearing induces functional changes in bone marrow derived mononuclear phagocytes

Bone marrow derived mononuclear phagocytes (BMDMP) differentiated in vitro from bone marrows of YAC-lymphoma bearing mice and Corynebacterium parvum (CP)-inflamed mice shown to differ in several functional parameters from those derived from bone marrows of control mice. The former 2 BMDMP populations expressed: (a) an increased level of acid phosphatase activity; (b) an increased degree of zymosan-induced chemiluminescence reaction; (c) a lower sensitivity of the proliferative capacity to prostaglandin E2 (PGE2), as compared to the BMDMP population from normal mice. These data suggest that YAC-lymphoma bearing in A/J mice induces similarly to inflammatory stimuli changes in the functional capacity of bone marrow mononuclear phagocyte precursor cells.