Study of prostaglandins E1 and F2 alpha on isolated mammalian cardiac tissue

Prostaglandins (PG) E1 and F2 alpha over a dose range of 2.0 pg/ml to 15 micrograms/ml were tested to determine if they had an effect on the resting potential, action potential amplitude, or action potential duration of isolated superfused canine cardiac Purkinje fibers or feline papillary muscles. The effect of the PGs on spontaneous rate in Purkinje fibers was also tested. PGE1 and PGF2 alpha over a range of 1.0 pg/ml to 20 micrograms/ml were tested to determine if these compounds had an inotropic effect on feline papillary muscle. The data show that in the range of concentrations tested, PGE1 and PGF2 alpha do not significantly change the electrophysiologic or mechanical response tested.