Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Analgesics and asthma

M Margolis, K K Mohan

    Southern Medical Journal
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Aspirin and other analgesics can trigger asthma attacks in 10-15% of patients by inhibiting prostaglandin synthesis. Careful avoidance of these drugs is key for managing this aspirin-exacerbated respiratory disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    NATURAL DISASTER and SOCIOECONOMIC CHANGE: POST-FROST ADJUSTMENTS IN PARANÁ, BRAZIL*.

    Disasters·2010
    Same author

    Temperature oscillations in the north atlantic.

    Science (New York, N.Y.)·2007
    Same author

    Sarcoidosis: still a mystery?

    Proceedings (Baylor University. Medical Center)·2005
    Same author

    Mega scrotum in pyoderma fistulans sinifica (fox den disease).

    Surgical infections·2003
    Same author

    Biliary web--a rare cause of extrahepatic biliary obstruction.

    Digestive surgery·2001
    Same author

    Closure of the abdominal midline fascia: meta-analysis delineates the optimal technique.

    The American surgeon·2001
    Same journal

    The Five Essential Concepts of Developmental Medicine: A Medical Paradigm for People with Developmental Disabilities.

    Southern medical journal·2026
    Same journal

    α-Gal Syndrome in the South: Why We Need Treatment Trials, Not Just Tick Prevention.

    Southern medical journal·2026
    Same journal

    Association between Main Pancreatic Duct Size, Comorbidities, and Fistula Formation after Whipple Procedure for Pancreatic Cancer.

    Southern medical journal·2026
    Same journal

    Impact of Temperature Variation on Patients with Acute Severe Asthma.

    Southern medical journal·2026
    Same journal

    Assessing the Accuracy and Reliability of ChatGPT-4 to Answer Clinical EHR Messages in Sports Medicine.

    Southern medical journal·2026
    Same journal

    Diagnostic Utility and Clinical Implications of Inpatient Fecal Occult Blood Testing.

    Southern medical journal·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Pulmonology
    • Immunology

    Background:

    • Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) pose risks for a subset of asthma patients.
    • This condition, affecting 10-15% of asthmatics, is characterized by a specific clinical presentation.
    • Diagnosis relies on patient history and sometimes requires specific drug challenge tests.

    Purpose of the Study:

    • To elucidate the mechanisms underlying analgesic-induced asthma exacerbations.
    • To outline diagnostic and management strategies for patients with this sensitivity.
    • To explore potential therapeutic advancements for aspirin-exacerbated respiratory disease.

    Main Methods:

    • Literature review of clinical cases and pharmacological studies.
    • Analysis of the role of prostaglandin synthesis inhibition.

    Related Experiment Videos

  • Examination of diagnostic criteria and treatment protocols.

    • Main Results:

    • Analgesics trigger bronchoconstriction by inhibiting prostaglandin synthesis, leading to the release of mediators like SRS-A.
    • Effective management primarily involves identifying and avoiding causative prostaglandin synthesis inhibitors.
    • Alternative medications and therapies like corticosteroids and disodium cromoglycate may be necessary for persistent symptoms.

    Conclusions:

    • Understanding the link between prostaglandin inhibition and asthma exacerbations is crucial.
    • Early recognition and avoidance of triggering analgesics are paramount for patient safety.
    • Ongoing research into prostaglandins may offer new therapeutic avenues for managing aspirin-exacerbated respiratory disease.