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Aminolevulinate dehydratase (E.C. 4.2.1.24): linkage analysis
Human Genetics
|January 1, 1982
Summary
Genetic linkage analysis excluded close association between aminolevulinate dehydratase (ALADH) and numerous human markers. Some evidence suggests a possible linkage with the HPA system in families from Germany.
Area of Science:
- Human genetics
- Biochemistry
- Population genetics
Background:
- Aminolevulinate dehydratase (ALADH) is a key enzyme in heme biosynthesis.
- Understanding the genetic locus of ALADH is important for human genetic mapping.
- Previous studies have investigated the linkage of ALADH with various genetic markers.
Purpose of the Study:
- To investigate the genetic linkage of aminolevulinate dehydratase (ALADH) with several human genetic markers.
- To determine the chromosomal location of the ALADH gene through family studies.
Main Methods:
- Family-based linkage analysis was performed.
- One hundred and two families from southwestern Germany were studied.
- ALADH enzyme activity and various genetic markers (Rh, PGM1, Fy, ACP1, MNSs, HLA, Bf, GLO, PGM3, Jk, Pi, PGP, K, GPT, HPA) were analyzed.
Main Results:
- Close linkage (theta = 0.05) between ALADH and Rh, PGM1, Fy, ACP1, MNSs, HLA, Bf, GLO, PGM3, Jk, Pi, PGP, K, and GPT was excluded.
- Evidence of possible linkage was found between ALADH and the HPA system.
Conclusions:
- The ALADH gene is not closely linked to a majority of the tested human genetic markers.
- The HPA system is a potential candidate for linkage with ALADH, warranting further investigation.