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Properdin factor B and acute lymphocytic leukemia (ALL)

B Budowle, R T Acton, B O Barger

|December 1, 1982

Summary

The Properdin factor B (Bf) locus is associated with childhood acute lymphoblastic leukemia (ALL). The Bf F allele increases ALL risk, while the Bf S allele offers protection.

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Area of Science:

Immunogenetics
Hematology
Human Genetics

Background:

The Properdin factor B (Bf) locus, a gene involved in the alternative complement pathway, has been investigated for its potential role in various diseases.
Genetic variations within the Bf locus may influence immune responses and susceptibility to certain conditions.

Purpose of the Study:

To investigate the association between the Properdin factor B (Bf) locus and acute lymphoblastic leukemia (ALL).
To determine if specific Bf alleles or phenotypes correlate with ALL risk or protection.

Main Methods:

A case-control study comparing 164 ALL patients with 545 healthy controls.
Analysis of Bf gene frequencies and phenotypes at the Properdin factor B locus.
Immune phenotyping was performed on 90 ALL patients.

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Main Results:

A significant association was found between the Bf F allele and an increased risk of ALL (relative risk = 3.62).
Individuals homozygous for the Bf S allele exhibited a significantly reduced risk of developing ALL (relative risk = 0.30).
Specific Bf genotypes (Bf SS and Bf FF) were differentially associated with non-B/T cell and pre-B cell types of ALL, respectively.

Conclusions:

The Properdin factor B (Bf) locus is significantly associated with susceptibility and protection in acute lymphoblastic leukemia (ALL).
These findings suggest the involvement of genes linked to the Bf locus in the pathogenesis or prevention of ALL.