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Cell adhesion molecules in early chicken embryogenesis

J P Thiery, J L Duband, U Rutishauser

    Proceedings of the National Academy of Sciences of the United States of America
    |November 1, 1982
    PubMed
    Summary
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    Neural cell adhesion molecule (N-CAM) is present in early chicken embryos, particularly in areas crucial for development and inductive events. This suggests N-CAM plays a key role in embryogenesis and tissue formation.

    Area of Science:

    • Developmental Biology
    • Cell Adhesion
    • Neuroscience

    Background:

    • Neural cell adhesion molecule (N-CAM) is a key protein involved in cell-cell interactions.
    • Understanding N-CAM distribution is crucial for deciphering early developmental processes.

    Purpose of the Study:

    • To map the expression patterns of N-CAM in the early chicken embryo (1-5 days).
    • To investigate the potential role of N-CAM in embryonic induction and histogenesis.

    Main Methods:

    • Fluorescent antibody techniques were employed to visualize N-CAM distribution.
    • Analysis focused on specific embryonic regions known for inductive events and axis formation.

    Main Results:

    • N-CAM was detected in regions of primary axis induction, including the neural plate, neural tube, notochord, and somites.

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  • Dynamic N-CAM staining was observed in later inductive sites like neural crest cells, placodes, cardiac mesoderm, and limb buds.
  • N-CAM expression patterns varied dynamically, appearing early, disappearing during migration, and reappearing during ganglion formation in neural crest cells.

    • Conclusions:

    • N-CAM is widely distributed in critical regions of the early chicken embryo.
    • The dynamic expression patterns suggest N-CAM-mediated adhesion is vital for both early embryogenesis and later histogenesis.