Gallium scans in Paget's sarcoma

Bone and gallium scans were performed in twelve patients with Paget's sarcoma. Most of these patients had polyostotic Paget's disease. The lesions with sarcomatous changes were usually associated with less Tc-99m MDP uptake as compared with Pagetoid bone which was not sarcomatous. Gallium uptake in the tumor area was proportionally higher than the MDP uptake and appeared quite irregular. Follow-up scans were available in a limited number of patients. Temporary response to chemotherapy was reflected by the decreased gallium uptake in the tumor area. Gallium scans appear to be useful in confirming the diagnosis of Paget's sarcoma and may be valuable in monitoring therapeutic response.