Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How many polymorphic genes will it take to span the human genome?

K Lange, M Boehnke

    American Journal of Human Genetics
    |November 1, 1982
    PubMed
    Summary

    Determining the number of polymorphic marker loci needed for a saturated human gene map requires careful consideration of genome coverage. Random marker distribution necessitates a larger number of loci than initially estimated for precise genetic mapping.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Exploring the psychosocial implications of general population screening for paediatric type 1 diabetes in Europe: Protocol for a mixed-methods study.

    Diabetic medicine : a journal of the British Diabetic Association·2026
    Same author

    Human factor in the use of automated insulin delivery systems: Real-world effects in children with type 1 diabetes after 2 years of use (AID-A study).

    Diabetes research and clinical practice·2025
    Same author

    A very rare case of osseous involvement of the dens axis in a 52-year-old HIV positive patient as part of secondary syphilis.

    Infection·2025
    Same author

    Scar endometriosis, a form of abdominal wall endometriosis-a neglected obstetrical complication?

    Archives of gynecology and obstetrics·2024
    Same author

    ISPAD Position Statement on Type 1 Diabetes in Schools.

    Hormone research in paediatrics·2024
    Same author

    Findings from three methods to identify falls in hospitals: Results from the Ambient Intelligent Geriatric Management system fall prevention trial.

    Australasian journal on ageing·2023

    Area of Science:

    • Human genetics
    • Population genetics
    • Genomic mapping

    Background:

    • Classical pedigree methods are used for genetic mapping.
    • A saturated gene map requires precise localization of human genetic loci to specific chromosomal regions.
    • Understanding the number of required polymorphic markers is crucial for achieving this goal.

    Purpose of the Study:

    • To estimate the number of polymorphic marker loci needed for a saturated human genetic map.
    • To assess the feasibility of achieving a saturated gene map using classical pedigree methods with a given marker density.

    Main Methods:

    • Theoretical calculation based on autosomal map length (33 morgans).
    • Formulation of marker density required for a locus to be within distance 'd' of a marker (33/(2d)).
    • Consideration of random marker distribution across the genome.

    Main Results:

    • Evenly spaced markers would require approximately 33/(2d) loci for a distance 'd'.
    • Random distribution of markers significantly increases the number of loci needed compared to even spacing.
    • A substantially larger number of loci must be isolated and tested to reach a saturated gene map.

    Conclusions:

    • Random marker distribution is a critical factor in estimating the required number of loci.
    • Achieving a saturated human gene map necessitates a greater number of polymorphic markers than simple spacing calculations suggest.
    • Further isolation and testing of genetic loci are required to fulfill the goal of a comprehensive gene map.

    Related Experiment Videos