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Related Experiment Videos

New selenium-containing silver amalgam

A Sato, Y Kumei

    The Bulletin of Tokyo Medical and Dental University
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Adding selenium to silver-tin amalgam alloy eliminated cell toxicity. Physical properties met American Dental Association standards, indicating a safer dental material.

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    Area of Science:

    • Biomaterials Science
    • Dental Materials Research
    • Toxicology

    Background:

    • Silver-tin amalgam is a widely used dental restorative material.
    • Concerns exist regarding the cytotoxicity of traditional dental amalgams.
    • Investigating modifications to improve amalgam biocompatibility is crucial.

    Purpose of the Study:

    • To evaluate the impact of selenium addition on the cytotoxicity of silver-tin amalgam.
    • To assess the physical properties of selenium-modified silver-tin amalgam.

    Main Methods:

    • Selenium (0.2-0.6 wt%) was incorporated into silver-tin amalgam alloy.
    • Cytotoxicity was assessed using the 51Cr release assay and cell morphology on L cells and JTC-12 cells.
    • Physical properties were tested following American Dental Association Specification No. 1.

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    Main Results:

    • Selenium addition (0.2-0.6 wt%) completely eliminated amalgam cytotoxicity.
    • Cell viability and morphology showed no adverse effects with selenium-modified amalgam.
    • Amalgam containing 0.2 wt% selenium met all tested physical property requirements.

    Conclusions:

    • Selenium is an effective additive for reducing or eliminating the cytotoxicity of silver-tin amalgam.
    • Selenium-modified silver-tin amalgam demonstrates promising biocompatibility and acceptable physical properties for dental applications.