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[Occurrence of HLA-antigens in patients with hypertrophic cardiomyopathy]
Insights
Human leukocyte antigen (HLA) tissue typing does not aid in diagnosing hypertrophic cardiomyopathy (HCM) or obstructive hypertrophic cardiomyopathy (HOCM). Frequencies of HLA antigens, including HLA-B-12, were similar in patients and healthy individuals.
Area of Science:
- Immunogenetics
- Cardiology
- Human leukocyte antigen (HLA) system
Context:
- The genetic basis of hypertrophic cardiomyopathy (HCM) and obstructive hypertrophic cardiomyopathy (HOCM) remains largely unknown.
- Previous studies have presented conflicting data regarding the association of specific human leukocyte antigen (HLA) antigens, such as HLA-B-12, with HCM and HOCM.
- Limited data exist on the prevalence of HLA-D antigens in patients with these conditions.
Purpose:
- To investigate the frequency of HLA-A, B, C, and DRW antigens in patients with HOCM and HCM compared to healthy controls.
- To determine if HLA tissue typing has diagnostic value for identifying patients with HOCM or HCM.
Summary:
- A microcytotoxicity test was used to analyze HLA antigen occurrence in 29 HOCM patients, 38 HCM patients, and matched healthy individuals.
- HLA antigen frequencies, including HLA-B-12, did not significantly differ between patients with HOCM/HCM and the control group.
- No significant differences were observed in HLA antigen occurrence between HOCM and HCM patient groups.
Impact:
- This study suggests that HLA tissue typing is not a valuable diagnostic tool for HCM or HOCM.
- The findings contribute to understanding the immunogenetic landscape of hypertrophic cardiomyopathies.
- Further research may explore other genetic or environmental factors contributing to HCM and HOCM etiology.
Abstract:
The etiology of hypertrophic cardiomyopathy with (HOCM) and without obstruction (HCM) is poorly understood. Controversial data have been published concerning the association of HLA-B-12-antigen with HOCM and HCM respectively. Further, HLA-D-antigen occurrence has been determined in few patients with HOCM or HCM. In 29 patients with HOCM, 38 patients with HCM, and matched healthy persons we determined the occurrence of HLA-A, B, C and DRW-antigen using the test of microcytotoxicity in lymphocytes. HLA-antigens occurred with similar frequency in patients with HOCM and HCM and in control subjects. 25% of the patients and 23% of the control subjects had HLA-B-12. Further, no difference was detected in the frequency of occurrence of HLA-antigens in patients with HOCM and in patients with HCM. The data support the view that HLA tissue typing is of no diagnostic value in identifying patients with HOCM or HCM.