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Comparative distribution of Baker's antifolate (NSC 139105) in rat tissues after subcutaneous and intravenous
Journal of Medicine
|January 1, 1980
Abstract:
The tissue distribution of BAF was compared by intravenous and subcutaneous injections in rats bearing Walker 256 carcinoma. Following a single dose (6 mg/kg containing 30 microCi 4,6-di-14C-BAF), the drug concentrations were determined by radiochemical and dihydrofolate reductase assays. The two methods gave comparable results. No metabolites were found by paper chromatographic separations.