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Related Experiment Videos

Experimental Corynebacterium equi infection in mice

M D Mutimer, J B Woolcock

    Journal of Reproduction and Fertility. Supplement
    |January 1, 1982
    PubMed
    Summary

    Normal mice can clear Corynebacterium equi infections, but high doses can cause pneumonia. Immune suppression with cyclophosphamide turns non-lethal challenges into fatal infections, impairing bacterial clearance.

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    Area of Science:

    • Immunology
    • Microbiology
    • Infectious Diseases

    Background:

    • Corynebacterium equi is a pathogen that can cause infections in various hosts.
    • Understanding the host-pathogen interaction and immune response is crucial for developing effective treatments.

    Purpose of the Study:

    • To investigate the in-vivo behavior of Corynebacterium equi in normal mice.
    • To determine the factors influencing bacterial clearance and disease development.
    • To evaluate the impact of immune suppression on infection outcome.

    Main Methods:

    • Intravenous, oral, subcutaneous, and intranasal challenge models in mice.
    • Bacterial enumeration in liver, spleen, and lung tissues.
    • Administration of immunosuppressive agents (carrageenan, cyclophosphamide).

    Main Results:

    • Mice generally cleared C. equi after intravenous challenge, with no signs of infection despite high bacterial loads.
    • Inoculum age and in-vitro growth temperature did not affect in-vivo growth or clearance.
    • Intranasal challenge with high doses of C. equi led to pneumonia.
    • Carrageenan treatment reduced bacterial clearance but not mortality.
    • Cyclophosphamide treatment converted non-lethal infections into fatal ones and impaired bacterial clearance.

    Conclusions:

    • Normal mice possess mechanisms to control C. equi infections.
    • High bacterial challenge doses or impaired immune function can lead to severe disease.
    • Immune status significantly influences the outcome of C. equi infections.

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