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Relaxin activity in foaling mares

D R Stewart, G H Stabenfeldt, J P Hughes

    Journal of Reproduction and Fertility. Supplement
    |January 1, 1982
    PubMed
    Summary
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    Plasma relaxin levels in pregnant mares surge during foaling and rapidly decline post-placenta delivery. Oxytocin administration may stimulate this relaxin increase, suggesting the placenta is the primary source.

    Area of Science:

    • Reproductive Endocrinology
    • Equine Physiology

    Background:

    • Relaxin is a key hormone in mammalian pregnancy.
    • Its role and secretion dynamics in mares around foaling require further elucidation.

    Purpose of the Study:

    • To investigate plasma relaxin concentrations in pregnant mares during natural and induced foaling.
    • To explore the potential role of oxytocin in relaxin secretion at foaling.

    Main Methods:

    • Radioimmunoassay measurement of hourly plasma relaxin concentrations.
    • Observation of mares during natural foaling and following oxytocin induction.
    • Analysis of relaxin levels relative to labor stages and placental expulsion.

    Main Results:

    • Natural foaling showed a pre-partum relaxin range of 4-7 ng/ml, surging to ~11 ng/ml during labor, and declining post-placenta.

    Related Experiment Videos

  • Oxytocin induction in 5/6 mares resulted in elevated relaxin peaking post-foaling.
  • One mare with retained placenta showed no relaxin decline until manual removal; further oxytocin increased relaxin.

    • Conclusions:

    • The placenta is likely the sole significant source of relaxin in pregnant mares.
    • Oxytocin may stimulate increased relaxin secretion during the foaling process.
    • Relaxin levels provide insights into equine parturition and placental health.