Uveitis associated with scleritis

In a clinical series of 350 eyes and a histopathological review of 100 globes, iridocyclitis was associated with scleritis in 42 and 63 per cent and choroiditis in 12 and 62 per cent respectively. Clinical, histological, and experimental evidence suggests that sclero-uveitis begins with a combination of immunological reactions. The host's individual immune response after foreign or self antigenic stimuli determines the presence, type, and extent of the scleral granulomatous inflammation and the uveal vasculitis. The presence of iridocyclitis accompanying scleritis offers presumptive evidence that a vasculitic process has extended to the inner structures of the globe and is an ominous sign of further complications and progressive visual loss.