Physiopathology of Fuchs's heterochromic cyclitis

The aetiopathogenesis of Fuchs's disease is still unknown. Recent findings indicate that the role of the sympathetic nervous system can be excluded and that the theory of heredodegeneration is a more probable explanation. A congenital predisposition to the disease which may possibly be related to some malformation of the iris vessels should be considered. This may explain why the disease is not always unilateral. The recent immunological anomalies found in the aqueous humour should be confirmed. Comparative studies of clinical, vascular, and immunological data could be of great interest in the future.