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Why do implants fail?

M A Galin, A W Tuberville, S A Obstbaum

    Transactions of the Ophthalmological Societies of the United Kingdom
    |January 1, 1981
    PubMed
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    Nylon 66 and polypropylene exhibit chemotaxis in human serum, unlike PMMA from intraocular lenses. Sterilization methods do not affect this inflammatory response, which may contribute to implant-related eye dysfunction.

    Area of Science:

    • Biomaterials science
    • Ophthalmology
    • Immunology

    Background:

    • Biomaterials like Nylon 66, polypropylene, and polymethyl methacrylate (PMMA) are used in medical implants, including intraocular lenses.
    • The body's inflammatory response to implanted materials can impact tissue function and lead to complications.

    Purpose of the Study:

    • To investigate the chemotactic activity of Nylon 66, polypropylene, and PMMA in human serum.
    • To determine if sterilization methods alter the chemotactic properties of these biomaterials.
    • To explore the potential role of chemotaxis in implant-induced ocular dysfunction.

    Main Methods:

    • Assessing chemotactic activity of Nylon 66, polypropylene, and PMMA using human serum.
    • Evaluating the effect of Ridley, 5% NaOH, and ethylene oxide sterilization on chemotaxis.

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    Main Results:

    • Nylon 66 and polypropylene demonstrated chemotactic activity in human serum.
    • PMMA, commonly used in intraocular lenses, did not exhibit chemotaxis.
    • Sterilization methods (Ridley, 5% NaOH, ethylene oxide) did not alter the chemotactic activity of the tested materials.

    Conclusions:

    • Chemotaxis is a material-dependent inflammatory response observed with Nylon 66 and polypropylene, but not PMMA.
    • Sterilization does not influence this specific inflammatory marker.
    • Chemotaxis may be a contributing factor to inflammatory processes causing corneal and retinal dysfunction after implantation of certain biomaterials.