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Visible changes of the lens with age
Transactions of the Ophthalmological Societies of the United Kingdom
|January 1, 1982
Summary
Human eye lens aging involves increased opacity and thickness, but decreased anterior disjunction zones. These zones are crucial for understanding age-related cataract development and progression.
Area of Science:
- Ophthalmology
- Biophysics
Background:
- Human eye lens aging is characterized by structural and optical changes.
- The anterior lens capsule and cortex undergo increased opacity and thickness with age.
Purpose of the Study:
- To investigate age-related changes in human lens optical properties using microdensitometry.
- To analyze the behavior of anterior disjunction zones in relation to aging and ocular conditions.
Main Methods:
- Slit lamp photographs of human eyes were analyzed using a microdensitometer.
- Quantitative measurements of lens nucleus, cortex, capsule, and disjunction zones were performed.
Main Results:
- Lens nucleus, cortex, and anterior capsule showed increasing opacity and thickness with age.
- Anterior disjunction zone opacity and width decreased with age.
- Ocular conditions like uveitis and glaucoma altered disjunction zone behavior.
Conclusions:
- Age-related changes in the human lens include increased opacity and thickness, with a concurrent decrease in anterior disjunction zones.
- The presence of anterior disjunction zone vestiges correlates with greater cortical fogging in incipient cataracts.
- Disruption of these zones may influence cataract development.