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[Post-transfusional hepatitis B: a solvable problem? (author's transl)]

R Stute, H Brüster, H Trobisch

    Deutsche Medizinische Wochenschrift (1946)
    |January 11, 1980
    PubMed
    Summary
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    This study found no hepatitis B transmission in 44 patients with haemophilia A or von Willebrand-Jürgens syndrome receiving over 28,000 cryoprecipitates. Even patients without prior hepatitis B antibodies remained safe, showing no adverse seroconversion or liver enzyme changes.

    Area of Science:

    • Hematology
    • Virology
    • Transfusion Medicine

    Context:

    • Haemophilia A and von Willebrand-Jürgens syndrome are bleeding disorders requiring regular blood product transfusions.
    • Cryoprecipitate is a common treatment, but carries a risk of viral transmission, including Hepatitis B.
    • Ensuring the safety of blood products is crucial for patient health.

    Purpose:

    • To evaluate the safety of cryoprecipitate produced in-house for patients with haemophilia A and von Willebrand-Jürgens syndrome.
    • To assess the risk of Hepatitis B transmission through cryoprecipitate transfusion.
    • To monitor for seroconversion and liver enzyme changes in at-risk patients.

    Summary:

    • Forty-four patients with haemophilia A or von Willebrand-Jürgens syndrome were monitored over three years.

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  • A total of approximately 28,000 cryoprecipitate units, produced in the author's laboratories, were administered.
  • No cases of Hepatitis B infection were observed, even in seven patients without pre-existing Hepatitis B surface antibodies who received 2533 units.

    • Impact:

    • This study demonstrates the safety of locally produced cryoprecipitate in preventing Hepatitis B transmission.
    • The findings support rigorous viral screening and in-house production protocols for blood products.
    • Highlights the importance of continued vigilance in transfusion-transmitted infections surveillance.