alpha-1-Antitrypsin phenotypes in French Canadian newborns

Cord blood sera from 390 French Canadian babies born consecutively in a Montreal hospital were phenotyped for alpha 1-antitrypsin. As in other populations, Pi M was the most frequent allele. The second most frequent was Pi S (0.0923). This Pi S allele frequency is significantly different from that of other Canadians, but similar to that of Normans and Bretons.