[Primary biliary cirrhosis associated with acute disseminated lupus erythematosus (author's transl)]

A 39 years old man experienced typical primary biliary (P.B.C.). Additional symptoms occured during the next four years including constitutional symptoms, polyarthralgias, nephrotic syndrom and chronic polyarthritis. Biologically, at the beginning of the disease, antimitochondrial antibodies were at the titer of 1/50,000, and the antinuclear antibodies at the titer of 1/10,000 (speckled pattern). During the course of the disease antimitochondrial antibodies decreased progressively and disappeared at the last control. The antinuclear antibodies progressed until 1/500,000 with anti Sm specificity. The association of P.B.C. and S.L.E., very seldom mentioned in the literature, is discussed among the auto-immune diseases.