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Human T lymphcytes are enriched for transfer factor

R H Tomar, P A John

    Journal of Immunology (Baltimore, Md. : 1950)
    |March 1, 1980
    PubMed
    Summary
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    Transfer factor, a substance derived from human immune cells, was tested in dogs. Results indicate transfer factor is primarily associated with T lymphocytes, suggesting it is a T cell lymphokine.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Transfer factor's biological role and cellular origin remain incompletely understood.
    • Investigating the cellular source of transfer factor is crucial for elucidating its immunobiology.

    Purpose of the Study:

    • To determine which subpopulation of human peripheral blood mononuclear cells contains transfer factor activity.
    • To investigate the cellular basis of transfer factor function.

    Main Methods:

    • A canine local skin assay was employed to assess transfer factor activity.
    • Human peripheral blood mononuclear cells were fractionated into subpopulations: T lymphocytes, adherent cells, and nonadherent/nonrosetting cells.

    Main Results:

    • Transfer factor activity was found to be enriched in the T lymphocyte subpopulation.

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  • Adherent cells and nonadherent/nonrosetting cells did not show enrichment for transfer factor activity.

    • Conclusions:

    • Transfer factor appears to be a lymphokine produced by T lymphocytes.
    • Further research is needed to clarify the immunobiology of transfer factor.