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Related Experiment Videos

Scanning electron microscopy of posterior polymorphous corneal dystrophy

F M Polack, W M Bourne, S L Forstot

    American Journal of Ophthalmology
    |April 1, 1980
    PubMed
    Summary

    Posterior polymorphous dystrophy, a genetic eye condition, involves endothelial cell degeneration and characteristic pits. Advanced lesions show abnormal Descemet

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    Area of Science:

    • Ophthalmology
    • Genetics
    • Cell Biology

    Background:

    • Posterior polymorphous dystrophy (PPMD) is a rare, inherited corneal disorder.
    • This case highlights a familial pattern of PPMD, emphasizing its genetic basis.
    • Keratoplasty was required for an 8 1/2-year-old girl with PPMD.

    Observation:

    • Scanning electron microscopy revealed endothelial cell degeneration and characteristic pits in the cornea.
    • Transmission electron microscopy showed an abnormal Descemet's membrane with multiple cell layers.
    • These advanced lesions are considered hallmarks of posterior polymorphous dystrophy.

    Findings:

    • The innermost corneal cells appeared endothelial-like under specular and scanning electron microscopy.
    • Abnormally developed Descemet's membrane was observed, covered by elongated endothelial-like cells.

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  • These cells deposited Descemet's membrane material and collagen fibrils, with distinct cellular organelles.

    • Implications:

    • Understanding the cellular mechanisms of PPMD is crucial for developing targeted treatments.
    • This study contributes to the histopathological characterization of posterior polymorphous dystrophy.
    • Further research into the genetic and cellular basis of PPMD may improve diagnostic and therapeutic strategies.