Prostaglandin E1 inhibition of acid but not gastrin

Prostaglandin E1, while inhibiting gastric fistula and Heidenhain pouch acid output in the dog, did not inhibit gastrin released by acetylcholine irrigation of an isolated antral pouch independent of pH effect. Some increase in gastrin was noted to PGE1 against a background of calcium infusion and following a meal. This increase is presumably due to acid inhibition and to an increase in intraluminal pH.