Successful pregnancy after occlusion therapy for high-titre sperm antibodies

A 32-year-old woman presented with a five-year history of primary infertility. In addition to anovulation associated with hyperprolactinaemia, she was found to have high titres of anti-sperm antibodies of agllutinating and immobilizing types. These were present in both serum and cervical mucus. After the regular use of condoms for nine months, all antibody titres fell dramatically and immobilizing antibodies became undetectable. Successful pregnancy quickly ensued. This report documents in thorough detail for the first time the sequential antibody changes associated with successful occlusion therapy.