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Related Experiment Videos

Cornea and ultraviolet radiation

A Ringvold

    Acta Ophthalmologica
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Ascorbic acid (AA) in corneal cells absorbs ultraviolet (UV) radiation similarly to proteins and nucleic acids below 290 nm. This suggests AA may mediate UV-induced photophthalmic damage, especially at shorter wavelengths.

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    Area of Science:

    • Ophthalmology
    • Photobiology
    • Biochemistry

    Background:

    • Corneal absorption of ultraviolet (UV) radiation is crucial for understanding photophthalmic damage.
    • Previous studies have focused on proteins and nucleic acids as primary UV absorbers in the cornea.

    Purpose of the Study:

    • To investigate the UV absorption properties of ascorbic acid (AA) in the cornea of various animal models.
    • To determine the role of AA in mediating UV-induced photophthalmic damage.

    Main Methods:

    • Studied UV radiation absorption in the corneas of rabbits, cats, guinea pigs, and rats.
    • Conducted model experiments simulating rabbit cornea epithelium conditions to assess AA's absorption contribution.

    Main Results:

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  • Rabbit and cat corneas absorbed ~80% of incident radiation at 290 nm, significantly more than guinea pig and rat corneas.
  • In rabbit cornea models, ascorbic acid exhibited UV absorption comparable to proteins and nucleic acids between 250-290 nm.

    • Conclusions:

    • Ascorbic acid is a significant absorber of UV radiation below 290 nm in the cornea.
    • AA may act as a phototoxic target, contributing to photophthalmic damage, particularly from shorter UV wavelengths.
    • AA's lower absorption above 290 nm suggests a lesser role in photophthalmic damage from solar radiation.