Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphologic abnormalities in potassium-deficient dogs

C L Tate, W J Bagdon, D L Bokelman

    The American Journal of Pathology
    |October 1, 1978
    PubMed
    Summary

    Potassium deficiency in dogs caused significant muscle and heart damage, along with kidney disease. This highlights the critical role of dietary potassium in maintaining canine health.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Plasmid DNA vaccines: assay for integration into host genomic DNA.

    Developments in biologicals·2001
    Same author

    Plasmid DNA vaccines: investigation of integration into host cellular DNA following intramuscular injection in mice.

    Intervirology·2001
    Same author

    Plasmid DNA vaccines: tissue distribution and effects of DNA sequence, adjuvants and delivery method on integration into host DNA.

    Intervirology·2001
    Same author

    Gender differences in toxicokinetics, liver metabolism, and plasma esterase activity: observations from a chronic (27-week) toxicity study of enalapril/diltiazem combinations in rats.

    Drug metabolism and disposition: the biological fate of chemicals·1996
    Same author

    Qualitative and quantitative evaluation of prostatic histomorphology in rats following chronic treatment with finasteride, a 5-alpha reductase inhibitor.

    Urology·1994
    Same author

    Leydig cell hyperplasia and adenomas in mice treated with finasteride, a 5 alpha-reductase inhibitor: a possible mechanism.

    Fundamental and applied toxicology : official journal of the Society of Toxicology·1994

    Area of Science:

    • Veterinary Pathology
    • Canine Nutrition
    • Renal Physiology

    Background:

    • Potassium is an essential electrolyte vital for cellular function.
    • Dietary potassium levels significantly impact physiological processes.
    • Understanding potassium deficiency effects is crucial for animal health.

    Purpose of the Study:

    • To investigate the morphological and physiological effects of potassium deficiency in dogs.
    • To identify specific organ systems affected by low dietary potassium.
    • To characterize the pathological changes associated with induced hypokalemia.

    Main Methods:

    • Induction of potassium deficiency in 16 dogs using a diet <0.03% potassium.
    • Monitoring of serum potassium levels over 3 weeks.
    • Histopathological examination of heart, skeletal muscle, and kidney tissues.

    Main Results:

    • Serum potassium decreased after 3 weeks in deficient dogs.
    • Focal myocardial necrosis observed in 6/16 dogs.
    • Skeletal muscle degeneration and necrosis in 14/16 dogs.
    • Complex nephropathy with collecting tubule epithelial changes in all dogs.

    Conclusions:

    • Potassium deficiency severely impacts canine cardiac, skeletal muscle, and renal systems.
    • Hypokalemia leads to distinct pathological changes in these organs.
    • Dietary potassium is critical for preventing severe tissue damage in dogs.

    Related Experiment Videos