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War gases as olfactory probes

D W Criswell, F L McClure, R Schaefer

    Science (New York, N.Y.)
    |October 1, 1980
    PubMed
    Summary
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    Ethyl bromoacetate, a tear gas, specifically blocks frog nose responses to esters while preserving sensitivity to amines. This suggests chemical warfare agents can act as precise probes for studying the sense of smell.

    Area of Science:

    • Olfactory neuroscience
    • Chemical toxicology

    Background:

    • The sense of smell relies on specific molecular interactions between odorants and olfactory receptors.
    • Chemical warfare agents, while harmful, possess distinct chemical properties that may allow for targeted biological interactions.

    Purpose of the Study:

    • To investigate the specific effects of ethyl bromoacetate, a lachrymator, on olfactory perception in frogs.
    • To explore the potential of chemical warfare agents as tools for probing olfactory mechanisms.

    Main Methods:

    • Exposure of frog olfactory systems to ethyl bromoacetate.
    • Testing olfactory responses to various odorants, including esters and amines.

    Main Results:

    • Ethyl bromoacetate impaired the frog nose's response to esters and other odorants.

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  • Sensitivity to amines remained unaffected by ethyl bromoacetate exposure.

    • Conclusions:

    • Ethyl bromoacetate exhibits selective action on olfactory perception, specifically targeting ester odorant detection.
    • Lachrymators and other chemical warfare agents with defined functional groups may serve as valuable chemical probes to dissect the complexities of the sense of smell.