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Related Experiment Video

Updated: Jul 8, 2026

Organoid-Derived Epithelial Monolayer: A Clinically Relevant In Vitro Model for Intestinal Barrier Function

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Published on: July 29, 2021

Functioning heterotopic oxyntic mucosa in the rectum

H T Debas, H Chaun, F B Thomson

Gastroenterology

|December 1, 1980

Summary

Heterotopic gastric mucosa in the rectum is rare and can mimic cancer. This study shows it can secrete acid, aiding surgical removal with pH-probe demarcation.

Area of Science:

Gastroenterology
Surgical Pathology

Background:

Heterotopic gastric mucosa in the rectum is an exceedingly rare condition.
It can present as rectal bleeding or a mass, necessitating differentiation from neoplastic lesions.

Observation:

A case of rectal heterotopic gastric mucosa is presented and reviewed with 9 prior reports.
This is the first reported instance of measurable acid secretion from this ectopic mucosa in response to pentagastrin.

Findings:

The heterotopic gastric mucosa demonstrated acid secretion upon pentagastrin stimulation.
A pH-probe, following pentagastrin administration, effectively demarcated the lesion.

Implications:

Accurate demarcation using pH-probe technology facilitates complete surgical excision of rectal heterotopic gastric mucosa.

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This finding enhances diagnostic and therapeutic strategies for this rare rectal anomaly.