Effect of prostaglandins on mouse erythrocyte rosette-forming human lymphocytes

Prostaglandins (PGs) E2 and F2 alpha, preincubated with human lymphocytes for short periods of time inhibit mouse erythrocyte rosette formation. The presence of calcium ions does not influence this effect, which is dose-dependent and relatively temperature-independent. These observations indicate the PG treatment of lymphocytes may be useful to distinguish a subclass of IgM-bearing mouse erythrocyte rosette-forming B lymphocytes, which is sensible to the modulating effect of Pgs.