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Acute pancreatitis associated with pentamidine therapy

S A Murphey, A S Josephs

    Archives of Internal Medicine
    |January 1, 1981
    PubMed
    Summary

    Pentamidine isethionate, used for Pneumocystis carinii pneumonia, may cause acute pancreatitis. Pancreatitis recurred in one patient upon retreatment with pentamidine, highlighting potential drug toxicity.

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Infectious Diseases

    Background:

    • Pentamidine isethionate is a crucial antimicrobial agent for treating Pneumocystis carinii pneumonia (PCP).
    • Understanding drug-induced toxicity is essential for patient safety and effective treatment protocols.

    Observation:

    • Two patients undergoing pentamidine isethionate treatment for PCP developed acute pancreatitis.
    • The onset of pancreatitis was temporally associated with the administration of pentamidine isethionate therapy.

    Findings:

    • A causal link between pentamidine isethionate and acute pancreatitis is suggested by the temporal relationship.
    • Recurrence of pancreatitis upon a second course of pentamidine in one patient strongly supports pentamidine-induced toxicity.

    Implications:

    • Clinicians should consider acute pancreatitis as a potential adverse effect of pentamidine isethionate.
    • Monitoring for pancreatitis symptoms in patients receiving pentamidine is recommended.
    • This finding necessitates further investigation into the mechanisms of pentamidine-induced pancreatitis.

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