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Endothelial function in patients with cornea guttata

R R Burns, W M Bourne, R F Brubaker

    Investigative Ophthalmology & Visual Science
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

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    Early Fuchs dystrophy is linked to increased corneal permeability and thickness, not altered endothelial cell size variability or pump rate. This suggests a primary barrier function defect in early disease stages.

    Area of Science:

    • Ophthalmology
    • Corneal Diseases
    • Cell Biology

    Background:

    • Fuchs' dystrophy is a progressive corneal disease.
    • Early stages may present without overt epithelial edema.
    • Understanding early functional changes is crucial for diagnosis and management.

    Purpose of the Study:

    • To investigate early functional and structural differences in the cornea between individuals with and without early Fuchs' dystrophy.
    • To identify the primary defect in the earliest stages of Fuchs' dystrophy.

    Main Methods:

    • Corneal thickness, endothelial cell size, endothelial permeability to fluorescein, and intraocular pressure were measured.
    • Two groups were studied: 21 individuals with cornea guttata and 17 age- and sex-matched controls with normal corneas.

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  • Endothelial pump rate was calculated.

    • Main Results:

    • Statistically significant differences were observed in corneal thickness, endothelial cell size, endothelial permeability, and intraocular pressure between the groups.
    • No significant difference was found in the variability of endothelial cell sizes.
    • Positive correlations existed between endothelial permeability, endothelial cell size, and corneal thickness.

    Conclusions:

    • The earliest defect in Fuchs' dystrophy appears to be a breakdown in endothelial barrier function, leading to increased permeability.
    • This increased permeability results in corneal edema and subsequent thickening.
    • Endothelial cell pump function is not significantly impaired in the early stages.