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Updated: Aug 18, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

[Changes in cellular and humoral immunity in the postoperative period (author's transl)]

R Kurz, K P Pfeiffer

    Zeitschrift Fur Kinderchirurgie Und Grenzgebiete
    |May 1, 1980
    PubMed

    Insights

    Post-surgery, infants and children experience a temporary drop in cellular immunity, particularly after major abdominal procedures. Humoral immunity remains unaffected, with IgM levels increasing post-operation.

    Area of Science:

    • Immunology
    • Pediatric Surgery

    Context:

    • Post-operative immune response in pediatric patients.
    • Impact of surgical procedures on immune function in children.
    • Age-related differences in immune deficiency after surgery.

    Purpose:

    • To investigate the impact of surgery on cellular and humoral immune defenses in infants and children.
    • To assess factors influencing post-operative immune status, including age and surgical complexity.

    Summary:

    • Surgery temporarily reduces E-rosettes forming lymphocytes, indicating a weakened cellular immune defense in pediatric patients.
    • This deficiency is more pronounced in newborns and infants undergoing major abdominal surgery.
    • Pre-operative complications correlate with lower initial immune values and increased risk of post-operative infections.
    • Humoral immune defense remains intact, with a notable increase in IgM concentrations post-surgery.

    Impact:

    • Highlights the transient nature of cellular immune deficiency following pediatric surgery.
    • Identifies newborns and infants as a vulnerable group requiring closer post-operative monitoring.
    • Suggests that pre-existing conditions significantly affect post-operative immune outcomes.
    • Provides insights into the differential impact of surgery on cellular versus humoral immunity.

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