Lysosomal enzyme activities in a case of T-cell chronic lymphocytic leukaemia

This study indicated that (i) high levels of N-acetyl-beta-glucosaminidase and beta-glucuronidase could be demonstrated cytochemically in T-CLL lymphocytes, and (ii), the biochemical activities of both enzymes were significantly increased in T-CLL lymphocytes compared with B-CLL lymphocytes. It would appear that the biochemical and cytochemical determination of these lysosomal enzyme activities offers an additional means of distinguishing T-CLL and B-CLL lymphocytes.