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[Suppression of bone marrow colony-forming capacity by syngeneic T-lymphocytes in AKR strain mice with lymphoblastic
The effect of lymphocytes from the lymph nodes and thymus on bone marrow colony-forming capacity was studied in AKR mice in the preleukemic and leukemic periods in vivo in the syngeneic donor-recipient system. In the pre-leukemic period, the lymphocytes do not change in the syngeneic stem cell colony-forming index, while in spontaneous lymphoblastic leukemia they suppress bone marrow proliferative activity both in normal and leukemic mice and 62-100%.
The effect of lymphocytes from the lymph nodes and thymus on bone marrow colony-forming capacity was studied in AKR mice in the preleukemic and leukemic periods in vivo in the syngeneic donor-recipient system. In the pre-leukemic period, the lymphocytes do not change in the syngeneic stem cell colony-forming index, while in spontaneous lymphoblastic leukemia they suppress bone marrow proliferative activity both in normal and leukemic mice and 62-100%.