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German Shepherd dog myelopathy--a morphologic and morphometric study

K G Braund, M Vandevelde

    American Journal of Veterinary Research
    |August 1, 1978
    PubMed
    Summary
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    German Shepherd Dog myelopathy is not a dying-back neurologic disease. Morphologic data suggest genetic factors may cause this condition in German Shepherd Dogs.

    Area of Science:

    • Veterinary Neurology
    • Canine Pathology
    • Genetics

    Background:

    • German Shepherd Dog myelopathy is a degenerative neurologic disease affecting the breed.
    • Previous hypotheses suggested a "dying-back" process as the underlying pathology.

    Purpose of the Study:

    • To investigate the morphologic and morphometric characteristics of German Shepherd Dog myelopathy.
    • To determine if the disease aligns with a "dying-back" neuropathic process.
    • To explore potential underlying causes, including genetic factors.

    Main Methods:

    • Evaluation of central and peripheral nervous system tissues from 23 affected German Shepherd Dogs.
    • Application of morphologic and morphometric analyses to characterize neuropathologic changes.

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    Main Results:

    • Morphologic and morphometric data did not support the "dying-back" disease concept for German Shepherd Dog myelopathy.
    • The study identified the disease complex as specific to the German Shepherd Dog breed.

    Conclusions:

    • The findings refute the "dying-back" hypothesis for German Shepherd Dog myelopathy.
    • The breed-specific occurrence strongly suggests a significant role for genetic determinants in the etiology of this neurologic condition.