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Related Experiment Videos

Expectation and patient preference -- does it matter?

H Berry, L Fernandes, B Bloom

    Journal of the Royal Society of Medicine
    |January 1, 1980
    PubMed
    Summary
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    Patient expectations vary in clinical trials for neck and shoulder pain. Tailoring trial inclusion criteria to patient-dominant needs, such as improved mobility, enhances drug efficacy demonstration.

    Area of Science:

    • Pharmacology
    • Clinical Research
    • Pain Management

    Background:

    • Clinical trial admission often assumes population homogeneity.
    • Patient expectations significantly influence perceived treatment outcomes.
    • Neck and shoulder pain affects a substantial patient population.

    Purpose of the Study:

    • To investigate the impact of patient expectations on clinical trial outcomes for neck and shoulder pain.
    • To determine if patient-dominant needs influence the demonstrable efficacy of anti-inflammatory analgesics.
    • To explore the heterogeneity of patient priorities in pain management trials.

    Main Methods:

    • A double-blind, placebo-controlled crossover study involving 60 patients with chronic neck or shoulder pain.
    • Patients assigned 100 points to various treatment benefits (pain relief, mobility, sleep, etc.) pre-treatment.

    Related Experiment Videos

  • Analogue scales used for response grading, side effect recording, and final preference establishment.

    • Main Results:

    • Patient priorities varied, with some valuing depression relief, sleep improvement, or reduced side effects over pain relief.
    • Differences between anti-inflammatory analgesics and placebo were most evident in patients prioritizing improved mobility.
    • Individual patient expectations influenced the perceived effectiveness of treatments.

    Conclusions:

    • Clinical trial homogeneity assumptions may not reflect real-world patient needs.
    • Selecting patients based on a dominant need (e.g., improved mobility) can better demonstrate specific drug properties.
    • This patient-centric approach may have broader implications for clinical trial design across various medical fields.