Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serologic studies in patients with keratoconjunctivitis sicca

S L Forstot, J Z Forstot, C L Peebles

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |May 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Erysipelothrix rhusiopathiae bloodstream infection - A 22-year experience at Mayo Clinic, Minnesota.

    Zoonoses and public health·2017
    Same author

    Ledipasvir/sofosbuvir fixed-dose combination for treatment of hepatitis C virus genotype 4 infection.

    Drugs of today (Barcelona, Spain : 1998)·2016
    Same author

    Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus. J. Immunol. 1966. 96: 464-471.

    Journal of immunology (Baltimore, Md. : 1950)·2006
    Same author

    Autoantibodies in prostate cancer.

    The New England journal of medicine·2005
    Same author

    Relative paradigms between autoantibodies in lupus and autoantibodies in cancer.

    Clinical and experimental immunology·2003
    Same author

    Autoantibodies as reporters identifying aberrant cellular mechanisms in tumorigenesis.

    The Journal of clinical investigation·2001
    Same journal

    The economics of the initial preventive physical examination in medicare-reply.

    Archives of ophthalmology (Chicago, Ill. : 1960)·2013
    Same journal

    Modification of silicone oil retention sutures in aphakic eyes with iris loss-reply;.

    Archives of ophthalmology (Chicago, Ill. : 1960)·2013
    Same journal

    December 2011 archives web quiz winner.

    Archives of ophthalmology (Chicago, Ill. : 1960)·2013
    Same journal

    Angle involvement and glaucoma in patients with biopsy-proven iris melanoma: a response-reply.

    Archives of ophthalmology (Chicago, Ill. : 1960)·2013
    Same journal

    About this journal.

    Archives of ophthalmology (Chicago, Ill. : 1960)·2013
    Same journal

    In memoriam: goodwin m. Breinin, MD (1918-2011).

    Archives of ophthalmology (Chicago, Ill. : 1960)·2013
    See all related articles

    Patients with dry eyes (keratoconjunctivitis sicca) often show abnormal antibody levels. Testing for antinuclear antibodies and Sjögren

    Area of Science:

    • Ophthalmology
    • Rheumatology
    • Immunology

    Background:

    • Keratoconjunctivitis sicca (KCS) is a common ocular condition.
    • The association between KCS and autoimmune markers requires further investigation.
    • Excluding patients with overt connective-tissue disease is crucial for understanding primary KCS-related autoimmunity.

    Purpose of the Study:

    • To investigate the prevalence of specific autoantibodies in patients diagnosed with KCS.
    • To determine if serologic abnormalities are common in KCS patients without connective-tissue disease.
    • To assess the utility of autoantibody testing in the early diagnosis of Sjögren's syndrome.

    Main Methods:

    • Screening of 32 KCS patients for antinuclear antibodies (ANA), rheumatoid factor (RF), and Sjögren's syndrome-associated autoantibodies (SS-A, SS-B).

    Related Experiment Videos

  • Clinical evaluation to exclude patients with evidence of connective-tissue disease.
  • Statistical analysis of serologic findings in relation to KCS diagnosis.

    • Main Results:

    • High positivity rates for ANA (59%) and RF (56%) were observed in KCS patients.
    • SS-A and/or SS-B autoantibodies were detected in 31% of the patients.
    • Serologic abnormalities were prevalent even after excluding patients with connective-tissue disease.

    Conclusions:

    • Patients with KCS exhibit a high incidence of serologic abnormalities, including ANA and RF.
    • Autoantibodies SS-A and SS-B are significantly associated with KCS and may indicate primary Sjögren's syndrome.
    • Serologic testing, particularly for SS-A and SS-B, is a valuable tool for early diagnosis and identifying KCS patients at risk for systemic complications.