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Three siblings with scleroderma (systemic sclerosis) and two with Raynaud's phenomenon from a single kindred
Arthritis and Rheumatism
|May 1, 1981
Summary
This study investigates inherited susceptibility to scleroderma and related conditions within a family. Findings suggest a genetic link, with the HLA-DRw4 antigen appearing in affected individuals and some asymptomatic relatives.
Area of Science:
- Genetics
- Immunology
- Rheumatology
Background:
- Scleroderma and Raynaud's phenomenon are complex autoimmune diseases.
- Familial aggregation suggests a potential inherited component.
- Connective tissue syndromes share overlapping clinical and immunological features.